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desvenlafaxine will boost the level or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, four hundred mg) reduce the CYP2D6 substrate dose by nearly fifty%; no dosage adjustment essential with desvenlafaxine doses seven consecutive days qui